An Innovative Approach to Understanding and Treating Cancer Targeting pH

An Innovative Approach to Understanding and Treating Cancer  Targeting pH
Author: Tomas Koltai,Stephan J. Reshkin,Salvador Harguindey
Publsiher: Academic Press
Total Pages: 574
Release: 2020-01-16
ISBN 10: 0128190604
ISBN 13: 9780128190609
Language: EN, FR, DE, ES & NL

An Innovative Approach to Understanding and Treating Cancer Targeting pH Book Review:

An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm, mechanisms to decrease extra cellular pH and increase intracellular pH, NHE-1 activity in cancer, carbonic anhydrases, vacuolar ATPase proton pump, and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions, cellular acidification and extracellular alkalinization as a new and integral approach to cancer treatment. Analyzes the mechanisms that lead to the inversion of pH gradient in cancer tissues Summarizes almost 100 years of research on pH inversion in cancer in one single source, discussing the most relevant and updated researches in the field Proposes new efficient treatments against cancer using pH inversion mechanisms, either with new drugs like proton transport inhibitors and proton pump inhibitors (PTIs and PPIs) or with repurposed drugs

Cancer Research Program Annual Report to the California State Legislature

Cancer Research Program Annual Report to the California State Legislature
Author: Cancer Research Program (Calif.)
Publsiher: Unknown
Total Pages: 329
Release: 2000
ISBN 10:
ISBN 13: UCR:31210017773605
Language: EN, FR, DE, ES & NL

Cancer Research Program Annual Report to the California State Legislature Book Review:

pH Interfering Agents as Chemosensitizers in Cancer Therapy

pH Interfering Agents as Chemosensitizers in Cancer Therapy
Author: Claudiu Supuran,Simone Carradori
Publsiher: Academic Press
Total Pages: 228
Release: 2020-09-15
ISBN 10: 0128209283
ISBN 13: 9780128209288
Language: EN, FR, DE, ES & NL

pH Interfering Agents as Chemosensitizers in Cancer Therapy Book Review:

pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume Thirteen, provides a detailed overview of the chemosensitizers for the treatment of cancer spanning from biochemical and structural features to pharmacology and drug-design, including technological applications. The book is structured with innovative outlines and a distinction between experimental and clinical results. The continuous discovery and assessment of the role played by old/new synthetic drugs, natural compounds and technological applications has led to the urgent need of classification in terms of biological activity, mechanism of action, clinical outcomes, cancer cell lines sensible to the treatment, and potentialities to better orient research in this field. Moreover, all the aspects relevant for medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, and molecular modeling studies) are strictly considered. Presents a broad view of the topic according to a medicinal chemistry-based approach beyond syntheses and biological assays, focusing on SAR studies, chemoinformatic, drug targeting and molecular modeling Explains the mechanism of action of the chemosensitizers by means of schemes and figures to facilitate comprehension Discusses novel targets to explore new possibilities that enhance research in the field

Prostate Cancer Metabolism

Prostate Cancer Metabolism
Author: Tomas Koltai,Stephan J. Reshkin,Fatima Baltazar,Larry Fliegel
Publsiher: Academic Press
Total Pages: 200
Release: 2021-07-01
ISBN 10: 032390551X
ISBN 13: 9780323905510
Language: EN, FR, DE, ES & NL

Prostate Cancer Metabolism Book Review:

Prostate Cancer Metabolism: From Biochemistry to Therapeutics shows the peculiarities of prostate cancer metabolism, emphasizing the targetable aspects – that have not been considered in conventional treatment protocols. The book specifically addresses treatment of the castration-resistant stage of prostate cancer proposing many repurposed drugs and nutraceuticals to complement, not replace, standard therapies. The large body of evidence supporting these concepts makes them deserving of further research and well-designed clinical trials. It discusses lipid, cholesterol, glutamine, and glucose metabolisms and their impact on prostate cancer. Additionally, it explains how current established drugs can be repurposed to improve treatment outcomes. The concepts set out in the book, that deal with cancer at the cellular/molecular level, help identify new avenues of research and treatments to pursue that do not affect well-being whilst offer consistent benefits. Since most practicing physicians have not studied basic biochemistry since medical school, each chapter begins with a brief review of the topic to facilitate an understanding of the metabolically-oriented approach to targeting prostate cancer. Conventional treatments are not discussed here since they are covered in textbooks and specialized updates that abound in the medical literature. It is a valuable resource for cancer researchers, oncologists, clinicians and members of biomedical field who want to learn more about prostate cancer metabolism and how to apply recent findings in the field to bedside. Explains the basic aspects of prostate cancer metabolism, including its biochemistry which has a pivotal role in clinical practice Discusses new drugs and nutraceuticals with a metabolism-centered approach Offers practical bedside approach in combination with molecular and biochemical fundamentals to help readers identify and provide the best treatment to their patients

Cancer Treatment

Cancer Treatment
Author: Letícia Rangel
Publsiher: BoD – Books on Demand
Total Pages: 630
Release: 2013-05-09
ISBN 10: 9535110985
ISBN 13: 9789535110989
Language: EN, FR, DE, ES & NL

Cancer Treatment Book Review:

Cancer Treatment: Conventional and Innovative Approaches is an attempt to integrate into a book volume the various aspects of cancer treatment, compiling comprehensive reviews written by an international team of experts in the field. The volume is presented in six sections: i) Section 1: Cancer treatment: Conventional and innovative pharmacological approaches; ii) Section 2: Combinatorial strategies to fight cancer: Surgery, radiotherapy, backytherapy, chemotherapy, and hyperthermia; iii) Section 3: The immunotherapy of cancer; iv) Section 4: Multidisciplinarity in cancer therapy: nutrition and beyond; v) Section 5: Supportive care for cancer patients; vi) Section 6: Perspectives in cancer biology and modeling. Ultimately, we hope this book can enlighten important issues involved in the management of cancer, summarizing the state-of-the-art knowledge regarding the disease control and treatment; thus, providing means to improve the overall care of patients that daily battle against this potentially lethal condition.

Nanotechnology

Nanotechnology
Author: Bhaskar Mazumder,Subhabrata Ray,Paulami Pal,Yashwant Pathak
Publsiher: CRC Press
Total Pages: 455
Release: 2019-03-18
ISBN 10: 1351111868
ISBN 13: 9781351111867
Language: EN, FR, DE, ES & NL

Nanotechnology Book Review:

Today we find the applications of nanotechnology in all spheres of life. Nanotechnology: Therapeutic, Nutraceutical and Cosmetic Advances discusses recent advances in the field, particularly with therapeutics, nutraceuticals and cosmetic sciences. Therapeutics is an area which has perhaps benefitted the most, although nanoscience and technology have quietly entered the realms of food science and are playing pivotal roles in the efficient utilization of nutraceuticals. Finally, even before therapeutics came cosmetics and companies started marketing unique products embedding the beneficial and advanced properties enabled by the use of nanostructures. This book highlights trends and applications of this wonderful new technology.

Molecular Oncology Underlying Mechanisms and Translational Advancements

Molecular Oncology  Underlying Mechanisms and Translational Advancements
Author: Ammad Ahmad Farooqi,Muhammad Ismail
Publsiher: Springer
Total Pages: 302
Release: 2017-03-29
ISBN 10: 3319530828
ISBN 13: 9783319530826
Language: EN, FR, DE, ES & NL

Molecular Oncology Underlying Mechanisms and Translational Advancements Book Review:

Cancer is a multifaceted and genomically complex disease and data obtained through high throughput technologies has provided near complete resolution of the landscape of how genomic, genetic and epigenetic mutations in cancerous cells effectively influence homeostasis of signaling networks within these cells, between cancerous cells, tumor microenvironment and at the organ level. Increasingly sophisticated information has helped us in developing a better understanding of the underlying mechanisms of cancer, and it is now known that intra-tumor genetic heterogeneity, cellular plasticity, dysregulation of spatio-temporally controlled signaling cascades, and loss of apoptosis are contributory in cancer development, progression and the development of resistance against different therapeutics. It is becoming progressively more understandable that earlier detection of pre-existing or emerging resistance against different therapeutics may prove to be helpful in personalizing the use of targeted cancer therapy. Despite the fact that there is a continuously increasing list of books, being guest edited by researchers, books on the subject are often composed of invited reviews without proper sequence and continuity and designed for a particular readership. This book progressively shifts and guides the readers from basic underlying mechanisms to translational approaches to treat cancer.

Nanotechnology Applications for Cancer Chemotherapy

Nanotechnology Applications for Cancer Chemotherapy
Author: Sanyog Jain,Kaisar Raza,Ashish Kumar Agrawal,Ankur Vaidya
Publsiher: Elsevier
Total Pages: 702
Release: 2020-10-01
ISBN 10: 0128178477
ISBN 13: 9780128178478
Language: EN, FR, DE, ES & NL

Nanotechnology Applications for Cancer Chemotherapy Book Review:

Applications of Nanotechnology in Cancer Chemotherapy offers a complete and concise summary of nanotechnological interventions for cancer management. It highlights the basics of oncology, the cancer microenvironment, targets for active drug delivery, the underlying mechanisms and molecular pathways to enhance the drug delivery to the cancer site. The book discusses the principles of basic and innovative nanocarrier-based therapeutic approaches to modulate the progression of the disease. In addition, this book also explores the evolving targeting approaches specific to the cancer site and type. The scope of the book is not limited to targeted drug delivery for various cancers, but also explores the advancements in cancer imaging and diagnostics employing the nanotechnological tools. Emphasis has been given on the important evaluation techniques like in-vitro cell culture and in-vivo animal models to assess the performance of cancer nanomedicines. The book includes clinical study reports of various drug moieties explored using variety of nanoconstructs in myriad cancer conditions with the input of global market and pharmacoeconomics. Discusses how organic and inorganic nanoplatforms are being used in cancer treatment Shows how nanotechnology is being used to create new and more accurate diagnostic tools Surveys the current generation of cancer nanomedicines, assessing their advantages and challenges

Wiley Encyclopedia of Chemical Biology Volume 3

Wiley Encyclopedia of Chemical Biology  Volume 3
Author: Tadhg P. Begley
Publsiher: Wiley
Total Pages: 828
Release: 2009-02-03
ISBN 10: 9780470470190
ISBN 13: 0470470194
Language: EN, FR, DE, ES & NL

Wiley Encyclopedia of Chemical Biology Volume 3 Book Review:

The first major reference at the interface of chemistry, biology, and medicine Chemical biology is a rapidly developing field that uses the principles, tools, and language of chemistry to answer important questions in the life sciences. It has enabled researchers to gather critical information about the molecular biology of the cell and is the fundamental science of drug discovery, playing a key role in the development of novel agents for the prevention, diagnosis, and treatment of disease. Now students and researchers across the range of disciplines that use chemical biology techniques have a single resource that encapsulates what is known in the field. It is an excellent place to begin any chemical biology investigation. Major topics addressed in the encyclopedia include: Applications of chemical biology Biomolecules within the cell Chemical views of biology Chemistry of biological processes and systems Synthetic molecules as tools for chemical biology Technologies and techniques in chemical biology Some 300 articles range from pure basic research to areas that have immediate applications in fields such as drug discovery, sensor technology, and catalysis. Novices in the field can turn to articles that introduce them to the basics, whereas experienced researchers have access to articles exploring the cutting edge of the science. Each article ends with a list of references to facilitate further investigation. With contributions from leading researchers and pioneers in the field, the Wiley Encyclopedia of Chemical Biology builds on Wiley's unparalleled reputation for helping students and researchers understand the crucial role of chemistry and chemical techniques in the life sciences.

Medicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs
Author: Carmen Avendano,J. Carlos Menendez
Publsiher: Elsevier
Total Pages: 768
Release: 2015-06-11
ISBN 10: 0444626670
ISBN 13: 9780444626677
Language: EN, FR, DE, ES & NL

Medicinal Chemistry of Anticancer Drugs Book Review:

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Cancer Stem Cells

Cancer Stem Cells
Author: Lucie Laplane
Publsiher: Harvard University Press
Total Pages: 252
Release: 2016-06-06
ISBN 10: 0674088743
ISBN 13: 9780674088740
Language: EN, FR, DE, ES & NL

Cancer Stem Cells Book Review:

A new therapeutic strategy could break the stalemate in the war on cancer by targeting not all cancerous cells but the small fraction that lie at the root of cancers. Lucie Laplane offers a comprehensive analysis of cancer stem cell theory, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy.

Developing Technologies for Early Detection of Breast Cancer

Developing Technologies for Early Detection of Breast Cancer
Author: National Research Council,Commission on Life Sciences,Institute of Medicine,National Cancer Policy Board,Committee on the Early Detection of Breast Cancer,Laura Newman
Publsiher: National Academies Press
Total Pages: 24
Release: 2000-08-06
ISBN 10: 0309071356
ISBN 13: 9780309071352
Language: EN, FR, DE, ES & NL

Developing Technologies for Early Detection of Breast Cancer Book Review:

In November 1999, the Institute of Medicine, in consultation with the Commission on Life Sciences, the Commission on Physical Sciences, Mathematics, and Applications, and the Board on Science, Technology and Economic Policy launched a one year study on technologies for early detection of breast cancer. The committee was asked to examine technologies under development for early breast cancer detection, and to scrutinize the process of medical technology development, adoption, and dissemination. The committee is gathering information on these topics for its report in a number of ways, including two public workshops that bring in outside expertise. The first workshop on "Developing Technologies for Early Breast Cancer Detection" was held in Washington DC in February 2000. The content of the presentations at the workshop is summarized here. A second workshop, which will focus on the process of technology development and adoption, will be held in Washington, DC on June 19-20. A formal report on these topics, including conclusions and recommendations, will be prepared by the committee upon completion of the one-year study.

Breast Cancer

Breast Cancer
Author: Umberto Veronesi,Aron Goldhirsch,Paolo Veronesi,Oreste Davide Gentilini,Maria Cristina Leonardi
Publsiher: Springer
Total Pages: 928
Release: 2017-11-03
ISBN 10: 3319488481
ISBN 13: 9783319488486
Language: EN, FR, DE, ES & NL

Breast Cancer Book Review:

This book provides the reader with up-to-date information on important advances in the understanding of breast cancer and innovative approaches to its management. Current and emerging perspectives on genetics, biology, and prevention are first discussed in depth, and individual sections are then devoted to pathology, imaging, oncological surgery, plastic and reconstructive surgery, medical oncology, and radiotherapy. In each case the focus is on the most recent progress and/or state of the art therapies and techniques. Further topics to receive detailed consideration include particular conditions requiring multidisciplinary approaches, the investigation of new drugs and immunological agents, lifestyle and psychological aspects, and biostatistics and informatics. The book will be an excellent reference for practitioners, interns and residents in medical oncology, oncologic surgery, radiotherapy, pathology, and human genetics, researchers, and advanced medical students.

Multiple Sclerosis As A Neuronal Disease

Multiple Sclerosis As A Neuronal Disease
Author: Stephen Waxman
Publsiher: Elsevier
Total Pages: 496
Release: 2005-05-27
ISBN 10: 9780080489414
ISBN 13: 0080489419
Language: EN, FR, DE, ES & NL

Multiple Sclerosis As A Neuronal Disease Book Review:

This book examines the role of neurons in multiple sclerosis (MS) and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities. * Brings together the latest information from clinical, pathological, imaging, molecular, and pharmacological realms to explore the neurobiology of Multiple Sclerosis * Places MS in a new and important perspective that promises to open up new therapeutic avenues * Superbly illustrated and referenced

Genetic Engineering News

Genetic Engineering News
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2005
ISBN 10:
ISBN 13: STANFORD:36105121613702
Language: EN, FR, DE, ES & NL

Genetic Engineering News Book Review:

Cancer Drug Design and Discovery

Cancer Drug Design and Discovery
Author: Stephen Neidle
Publsiher: Elsevier
Total Pages: 496
Release: 2011-04-28
ISBN 10: 9780080554952
ISBN 13: 0080554954
Language: EN, FR, DE, ES & NL

Cancer Drug Design and Discovery Book Review:

The ultimate source of information on the design of new anticancer agents, emphasizing small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumors. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing to a broad audience, this is an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry and clinicians taking oncology options. * Covers both currently available drugs as well as those under development * Provides a clinical perspective on trials of new anticancer agents * Presents drug discovery examples through the use of case histories

Biomaterials for Cancer Therapeutics

Biomaterials for Cancer Therapeutics
Author: Kinam Park
Publsiher: Woodhead Publishing Limited
Total Pages: 810
Release: 2020-03
ISBN 10: 9780081029831
ISBN 13: 0081029837
Language: EN, FR, DE, ES & NL

Biomaterials for Cancer Therapeutics Book Review:

Cancer affects people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is being developed to target, treat, and prevent cancer. This book discusses the role and potential of biomaterials in treating this prevalent disease. The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Part Two discusses synthetic vaccines, proteins, and polymers for cancer therapeutics. Part Three focusses on theranosis and drug delivery systems, while the final set of chapters look at biomaterial therapies and cancer cell interaction. A complete overview of the latest research into the potential of biomaterials for the diagnosis, treatment, and prevention of cancer Discusses how the properties of specific biomaterials make them important in cancer treatment Discusses synthetic vaccines, proteins, and polymers for cancer therapeutics

Action in Perception

Action in Perception
Author: Alva Noe,Alva Noë,Alva·No鑕,Professor of Philosophy Alva No?
Publsiher: MIT Press
Total Pages: 277
Release: 2004
ISBN 10: 9780262140881
ISBN 13: 0262140888
Language: EN, FR, DE, ES & NL

Action in Perception Book Review:

An argument that perception is something we do, not something that happens to us: not a process in the brain, but a skillful bodily activity.

Smart Drug Delivery System

Smart Drug Delivery System
Author: Ali Demir Sezer
Publsiher: BoD – Books on Demand
Total Pages: 398
Release: 2016-02-10
ISBN 10: 9535122479
ISBN 13: 9789535122470
Language: EN, FR, DE, ES & NL

Smart Drug Delivery System Book Review:

This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different smart drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, diabetic, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Citrus

Citrus
Author: Pierre Laszlo
Publsiher: University of Chicago Press
Total Pages: 252
Release: 2008-10
ISBN 10: 0226470288
ISBN 13: 9780226470283
Language: EN, FR, DE, ES & NL

Citrus Book Review:

Laszlo traces the spectacular rise and spread of citrus across the globe, from southeast Asia in 4000 BC to modern Spain and Portugal, whose explorers inroduced the fruit to the Americas. This book explores the numerous roles that citrus has played in agriculture, horticulture, cooking, nutrition, religion, and art.