Alginates in Drug Delivery

Alginates in Drug Delivery
Author: Amit Kumar Nayak,Md Saquib Hasnain
Publsiher: Academic Press
Total Pages: 434
Release: 2020-07-23
ISBN 10: 0128176415
ISBN 13: 9780128176412
Language: EN, FR, DE, ES & NL

Alginates in Drug Delivery Book Review:

Alginates in Drug Delivery explores the vital precepts, basic and fundamental aspects of alginates in pharmaceutical sciences, biopharmacology, and in the biotechnology industry. The use of natural polymers in healthcare applications over synthetic polymers is becoming more prevalent due to natural polymers’ biocompatibility, biodegradability, economic extraction and ready availability. To fully utilize and harness the potential of alginates, this book presents a thorough understanding of the synthesis, purification, and characterization of alginates and their derivative. This book collects, in a single volume, all relevant information on alginates in health care, including recent advances in the field. This is a highly useful resource for pharmaceutical scientists, health care professionals and regulatory scientists actively involved in the pharmaceutical product and process development of natural polymer containing drug delivery, as well as postgraduate students and postdoctoral research fellows in pharmaceutical sciences. Provides a single source on the complete alginate chemistry, collection, chemical modifications, characterization and applications in healthcare fields Includes high quality illustrations, along with practical examples and research case studies Contains contributions by global leaders and experts from academia, industry and regulatory agencies who are pioneers in the application of natural polysaccharides in diverse pharmaceutical fields

Alginates

Alginates
Author: Md Saquib Hasnain,Amit Kumar Nayak
Publsiher: CRC Press
Total Pages: 626
Release: 2019-04-01
ISBN 10: 042965748X
ISBN 13: 9780429657481
Language: EN, FR, DE, ES & NL

Alginates Book Review:

This new volume explores the latest research on the use of alginate as a biopolymer in various biomedical applications and therapeutics. The uses of alginates and modified alginates discussed in this book include tissue regeneration, encapsulation and delivery of drugs, nucleic acid materials, proteins and peptides, genes, herbal therapeutic agents, nutraceuticals, and more. This book also describes the synthesis and characterizations of various alginate and modified alginate systems, such as hydrogels, gels, composites, nanoparticles, scaffolds, etc., used for the biomedical applications and therapeutics. Alginate, a biopolymer of natural origin, is of immense interest for its variety of applications in pharmaceuticals (as medical diagnostic aids) and in materials science. It is the one of the most abundant natural biopolymers and is considered an excellent excipient because of its non-toxic, stable, and biodegradable properties. Several research innovations have been made on applications of alginate in drug delivery and biomedicines. There needs to be a thorough understanding of the synthesis, purification, and characterization of alginates and its derivatives for their utility in healthcare fields, and this volume offers an abundance of information toward that end.

Alginates

Alginates
Author: Shakeel Ahmed
Publsiher: John Wiley & Sons
Total Pages: 336
Release: 2019-03-12
ISBN 10: 1119487919
ISBN 13: 9781119487913
Language: EN, FR, DE, ES & NL

Alginates Book Review:

Alginate is a hydrophilic, biocompatible, biodegradable, and relatively economical polymer generally found in marine brown algae. The modification in the alginate molecule after polymerization has shown strong potential in biomedical, pharmaceutical and biotechnology applications such as wound dressing, drug delivery, dental treatment, in cell culture and tissue engineering. Besides this, alginates have industrial applications too in the paper and food industries as plasticizers and additives. The few books that have been published on alginates focus more on their biology. This current book focuses on the exploration of alginates and their modification, characterization, derivatives, composites, hydrogels as well as the new and emerging applications.

Alginates and Their Biomedical Applications

Alginates and Their Biomedical Applications
Author: Bernd H.A. Rehm,M. Fata Moradali
Publsiher: Springer
Total Pages: 268
Release: 2017-11-29
ISBN 10: 9811069107
ISBN 13: 9789811069109
Language: EN, FR, DE, ES & NL

Alginates and Their Biomedical Applications Book Review:

This book presents a comprehensive review of the latest advances in developing alginate-based biomaterials and derivatives as well as their biomedical and pharmaceutical applications. It covers the physiochemical properties of alginates, production and formulation methods, derivatizations and characterization methods, the fundamental work on optimizing alginate polymers for defined biomedical purposes as well as the scope and effectiveness of their applications in medicine and therapeutic approaches. The book brings together new concepts and advances in harnessing alginate-based biomaterials in combination with applied technological advances to tailor their applications to medical needs. The contributions by leading academics, clinicians and researchers not only cover the fundamentals, but also open new avenues for meeting future challenges in research and clinical applications.

Natural Polysaccharides in Drug Delivery and Biomedical Applications

Natural Polysaccharides in Drug Delivery and Biomedical Applications
Author: Md Saquib Hasnain,Amit Kumar Nayak
Publsiher: Academic Press
Total Pages: 654
Release: 2019-07-23
ISBN 10: 0128170565
ISBN 13: 9780128170564
Language: EN, FR, DE, ES & NL

Natural Polysaccharides in Drug Delivery and Biomedical Applications Book Review:

Natural Polysaccharides in Drug Delivery and Biomedical Applications provides a fundamental overview of natural polysaccharides, their sources, extraction methodologies, and characterizations. It covers specific natural polysaccharides and their effective application in drug delivery and biomedical use. Additionally, chapters in the book discuss key topics including the sources and extraction methodologies of natural polysaccharides, their role in tissue engineering applications, polysaccharide-based nanoparticles in biomedical applications, and their role in the delivery of anticancer drugs. Written by industry leaders and edited by experts, this book emphasizes recent advances made in the field. Natural Polysaccharides in Drug Delivery and Biomedical Applications provides academics, researchers, and pharmaceutical health care professionals with a comprehensive book on polysaccharides in pharmaceutical delivery process. Provides fundamental concepts of natural polysaccharides as it applies to the pharmaceutical, biomedical, and biotechnology industries Includes contributions from global leaders and experts from academia, industry, and regulatory agencies in the application of natural polysaccharides in pharmaceutical products and biomedical utilization Offers practical examples, illustrations, chemical structures, and research case studies to help explain natural polysaccharides concepts in drug delivery and biomedical applications

Use of Alginate/montmorillonite Nanocomposites as Drug Delivery System for Curcumin

Use of Alginate/montmorillonite Nanocomposites as Drug Delivery System for Curcumin
Author: Marwa Fathy Abdelfattah Ahmed
Publsiher: Anonim
Total Pages: 162
Release: 2015
ISBN 10:
ISBN 13: OCLC:948661441
Language: EN, FR, DE, ES & NL

Use of Alginate/montmorillonite Nanocomposites as Drug Delivery System for Curcumin Book Review:

Abstract: Curcumin (Cur.) is a well known traditional medicine due to its anti-inflammatory and antioxidant properties. Its pharmacological mechanism of action and safety have been extensively studied to investigate its use in clinical and therapeutic applications. However, its low water solubility and rapid metabolism are main obstacles. Different techniques were used to overcome the drawbacks of curcumin, with recent attention focusing on approaches based on nanotechnology. Clay-polymer nanocomposites are getting to play a role in nanoformulations for drug delivery. This is due to their improved rheological and mechanical properties, and controlled drug release characteristics compared to their individual components, clays and polymers. Alginate/ montmorillonite (MMT) nanocomposites are used as drug delivery system for a wide variety of drugs due to numerous advantages of both components such as the high loading capacity of MMT and the ability of alginate release encapsulated drugs in a controlled manner. Accordingly, this study aimed at the preparation of curcumin loaded alginate/MMT nanocomposites and the investigation of their release properties. Exfoliated MMT clay was first prepared by stirring the clay in an aqueous suspension for 4 hours, followed by filtration and drying at 70 °C. Exfoliation was confirmed by X-ray diffraction (XRD) and Fourier Transform infrared (FTIR) spectroscopy. Curcumin loaded MMT was then prepared by dispersing the exfoliated clay into an ethanoic curcumin solution. Different parameters were tested, namely stirring time, curcumin solution concentration and ratio of MMT to curcumin, in order to find out the maximum loading conditions. Stirring exfoliated MMT into curcumin solution of 1 mg/ml for 1 hour and in 5% W/V ratio was found to be the best condition for maximum loading (6.56 mg/g, corresponding to entrapment efficiency of 25.62 %). The hybrid sample (curcumin loaded MMT) was thus prepared. Visible spectrophotometric measurements of the curcumin solution were used to determine the amount of curcumin loaded by measuring the absorbance of curcumin solution before and after the dispersion of the clay. The hybrid sample was then encapsulated into alginate beads with different hybrid to alginate ratios (W/W) using the ionotropic technique. XRD and FTIR analysis were used for the characterization of the prepared hybrid and nanocomposites. They revealed the increase in the degree of clay exfoliation upon drug loading and encapsulation into the alginate beads and the loss of the crystalline nature of curcumin upon v adsorption onto the clay surface without any chemical interaction between the clay and curcumin. The release of curcumin from different alginate/MMT nanocomposites was studied in different biorelevent media: fast gastric (FaSSGF), fast intestinal (FaSSIF) and fed intestinal media (FeSSIF). The curcumin release in gastric media was negligible and this was attributed to its low solubility in these media and to the shrinkage of alginate beads in the acidic pH environment. Curcumin release in intestinal media was significantly higher and was found to be affected by both the feeding state and the ratio of hybrid to alginate. Increasing the hybrid to alginate ratio decreased the percentage of curcumin release because of the decrease of the swelling ratio of alginate due to the crosslinking effect of the clay. Consequently, the 1:20 (W/W) hybrid to alginate ratio nanocomposite sample (NC 1) showed the highest release percentage in both fast and fed intestinal media (71% in the FaSSIF and 15.5 % in the FeSSIF). On the other hand, the 1:2 (W/W) hybrid to alginate ratio nanocomposite sample (NC 4) demonstrated the lowest release percentage in both media (17.4% in FaSSIF and 6.6 % in FeSSIF). The feeding state played additional role in the percentage of curcumin released as it was found to affect both the pH and the concentration of the natural solubilizing components such as phospholipids and bile salts of the intestine. Accordingly, the percentage of curcumin released was higher in the fasting state than in the fed state due to the higher pH of the former media (88.4% in the FaSSIF and 16.6% in the FeSSIF for NC 1. Curcumin release in both intestinal media demonstrated different behaviors: in FaSSIF sustained release behavior was found to occur for 24 hours, while curcumin release reached a plateau by 8 hours in the FeSSIF. This study reveals the promising use of alginate/MMT nanocomposites as sustained release drug delivery system for curcumin through surface adsorption of curcumin onto the surface of exfoliated clay and encapsulation of the loaded clay into alginate beads. The release of curcumin would be hindered into the gastric environment and start into the intestine. For maximum and sustained release behavior a fasting state is preferred.

Controlled Drug Delivery Systems

Controlled Drug Delivery Systems
Author: Emmanuel C. Opara
Publsiher: CRC Press
Total Pages: 351
Release: 2020-02-28
ISBN 10: 0429582757
ISBN 13: 9780429582752
Language: EN, FR, DE, ES & NL

Controlled Drug Delivery Systems Book Review:

This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book: Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projections Examines the advantages and disadvantages of each drug delivery system Examines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomes Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.

Oral Controlled Release Formulation Design and Drug Delivery

Oral Controlled Release Formulation Design and Drug Delivery
Author: Hong Wen,Kinam Park
Publsiher: John Wiley & Sons
Total Pages: 376
Release: 2011-01-14
ISBN 10: 9781118060322
ISBN 13: 1118060326
Language: EN, FR, DE, ES & NL

Oral Controlled Release Formulation Design and Drug Delivery Book Review:

This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.

Polysaccharides in Advanced Drug Delivery

Polysaccharides in Advanced Drug Delivery
Author: Akhilesh Vikram Singh,Bang-Jing Li
Publsiher: CRC Press
Total Pages: 198
Release: 2020-03-24
ISBN 10: 1000050866
ISBN 13: 9781000050868
Language: EN, FR, DE, ES & NL

Polysaccharides in Advanced Drug Delivery Book Review:

This book contains selective chapters from eminent experts working in the interdisciplinary arena of material science and its use in drug delivery. From their recent research experience, the readers can achieve a wide vision on the new and ongoing potentialities of polysaccharides and its application in the field of advanced drug delivery. This book contains selective polymers that were recently explored in the field of drug delivery such as starch, konjac, chitosan, alginate and other natural polymers originated from sea. It also has one chapter exclusively on nanotechnology that explains multifaceted application of natural polymer in the field of advanced drug delivery. Note: T& F does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka.

Alginates

Alginates
Author: Manuel E. Molina,Andres J. Quiroga
Publsiher: Nova Science Pub Incorporated
Total Pages: 272
Release: 2012
ISBN 10: 9781619425460
ISBN 13: 1619425467
Language: EN, FR, DE, ES & NL

Alginates Book Review:

Alginate is extracted from brown algae and some bacteria. It is an abundant natural polysaccharide and usually exists as sodium salt. In this book, the authors present topical research in the study of the production, types and applications of alginate. Topics discussed include the application of alginates in cell and enzyme immobilization; alginate based materials in environmental applications; cross-linked alginates for modified drug delivery applications; bacterial alginate production by fermentation and the preparation and functionalization of alginate-based hydrogels.

Plant Polysaccharides-Based Multiple-Unit Systems for Oral Drug Delivery

Plant Polysaccharides-Based Multiple-Unit Systems for Oral Drug Delivery
Author: Amit Kumar Nayak,Md Saquib Hasnain
Publsiher: Springer
Total Pages: 129
Release: 2019-03-27
ISBN 10: 9811067848
ISBN 13: 9789811067846
Language: EN, FR, DE, ES & NL

Plant Polysaccharides-Based Multiple-Unit Systems for Oral Drug Delivery Book Review:

This book explores the use of various plant polysaccharides for pharmaceutical purposes, including drug delivery. It examines the exploitation of plant polysaccharides’ auxiliary functions to enhance drug release, stability, bioavailability and target specificity. Plant-derived materials are at the center of drug-delivery research thanks to their non-toxicity, biodegradability, ready availability, eco-friendliness and low extraction costs. These materials include polysaccharides, a class of naturally occurring polymers consisting of glucose monomers, which serve as storage carbohydrates in cereals, root vegetables, rhizomes, seeds, fruits, etc.

Applications of Nanocomposite Materials in Drug Delivery

Applications of Nanocomposite Materials in Drug Delivery
Author: Dr Inamuddin,Abdullah M. Asiri,Ali Mohammad
Publsiher: Woodhead Publishing
Total Pages: 990
Release: 2018-06-18
ISBN 10: 0128137584
ISBN 13: 9780128137581
Language: EN, FR, DE, ES & NL

Applications of Nanocomposite Materials in Drug Delivery Book Review:

Applications of Nanocomposite in Drug Delivery discusses and explores the applications of nanocomposites in the area of drug delivery. Starting with a scientific understanding of drug delivery fundamentals, the book explores the utility of nanocomposites in the area of controlled, transdermal, osteo-articular tuberculosis and stimulus sensitive drug delivery applications. The book intricately details and discusses a variety of methods for their preparation, while also highlighting specific applications of nanocomposites in targeted drug delivery. Discusses nanocomposite and nanotechnology for drug delivery Outlines the mechanisms involved in targeted drug delivery using nanocomposites Includes synthesis methods for nanocomposites used in controlled drug delivery Lists various applications of nanocomposites in drug delivery

Advanced Biopolymeric Systems for Drug Delivery

Advanced Biopolymeric Systems for Drug Delivery
Author: Anonim
Publsiher: Springer Nature
Total Pages: 386
Release: 2020
ISBN 10: 3030469239
ISBN 13: 9783030469238
Language: EN, FR, DE, ES & NL

Advanced Biopolymeric Systems for Drug Delivery Book Review:

This book discusses the recent innovations in the development of various advanced biopolymeric systems, including gels, in situ gels, hydrogels, interpenetrating polymer networks (IPNs), polyelectrolyte complexes (PECs), graft co-polymers, stimuli-responsive polymers, polymeric nanoparticles, nanocomposites, polymeric micelles, dendrimers, liposomes and scaffolds. It also examines their applications in drug delivery.

Nanoarchitectonics for Smart Delivery and Drug Targeting

Nanoarchitectonics for Smart Delivery and Drug Targeting
Author: Alina Maria Holban,Alexandru Mihai Grumezescu
Publsiher: William Andrew
Total Pages: 970
Release: 2016-07-12
ISBN 10: 0323477224
ISBN 13: 9780323477222
Language: EN, FR, DE, ES & NL

Nanoarchitectonics for Smart Delivery and Drug Targeting Book Review:

Nanoarchitectonics for Smart Delivery and Drug Targeting is one of the first books on the market to exclusively focus on the topic of nanoarchitectonics, a rapidly developing area of nanotechnology which allows scientists to arrange nanoscale structural units, typically a group of atoms or molecules, in an intended configuration. This book assesses novel applications of nanomaterials in the areas of smart delivery and drug targeting using nanoarchitectonics and discusses the advantages and disadvantages of each application. Provides a scholarly introduction to the uses of nanoarchitectonics in drug delivery and targeting Explores novel opportunities and ideas for developing and improving nanoscale drug delivery systems through the use of nanoarchitectonics, allowing scientists to see how this exciting new technology is used in practice Assesses the pros and cons of each application, allowing readers to assess when it is most appropriate to use nanoarchitectonics in drug delivery

Food Hydrocolloids

Food Hydrocolloids
Author: Martin Glicksman
Publsiher: CRC Press
Total Pages: 240
Release: 2020-03-27
ISBN 10: 1000694313
ISBN 13: 9781000694314
Language: EN, FR, DE, ES & NL

Food Hydrocolloids Book Review:

First Published in 1982, this three-volume set explores the value of hydrocolloids in food. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for dieticians and other practitioners in their respective fields.

Biodegradable Hydrogels for Drug Delivery

Biodegradable Hydrogels for Drug Delivery
Author: Haesun Park,Kinam Park,Waleed S.W. Shalaby
Publsiher: CRC Press
Total Pages: 262
Release: 2011-07-08
ISBN 10: 9781439892961
ISBN 13: 1439892962
Language: EN, FR, DE, ES & NL

Biodegradable Hydrogels for Drug Delivery Book Review:

From the Authors' Preface The advances made in the area of controlled drug delivery during the last two decades are remarkable ....Of the many polymeric materials, biodegradable hydrogels present unique advantages and opportunities in the development of ...delivery devices....We have undertaken the challenge of putting together information relevant to biodegradable hydrogels in one place. This book covers the mechanisms of biodegradation, types of biodegradable hydrogels,chemical and physical gels, chemical and enzymatic degradation, and examples of biodegradable drug delivery systems.

Natural Polymers for Pharmaceutical Applications

Natural Polymers for Pharmaceutical Applications
Author: Amit Kumar Nayak,Md Saquib Hasnain,Dilipkumar Pal
Publsiher: CRC Press
Total Pages: 238
Release: 2019-10-16
ISBN 10: 1000576841
ISBN 13: 9781000576849
Language: EN, FR, DE, ES & NL

Natural Polymers for Pharmaceutical Applications Book Review:

This new volume, Natural Polymers for Pharmaceutical Applications, Volume 1: Plant-Derived Polymers, presents some of the latest research on the applications of natural polymers in drug delivery and therapeutics for healthcare benefits. Polymers and their applications from several plants are discussed in depth, including tamarind gum, gum Arabic, natural carbohydrate polymer gum tragacanth, pectin, guar gum and its derivatives, locust bean gum, sterculia gum, okra gum, and others. The use of the polymers derived from plants as potential pharmaceutical excipients is expanding day by day because of their stability in the biological system, drug-releasing capability, drug-targeting abilities, as well as their bioavailability.

Biological Activities and Application of Marine Polysaccharides

Biological Activities and Application of Marine Polysaccharides
Author: Emad Shalaby
Publsiher: BoD – Books on Demand
Total Pages: 328
Release: 2017-01-11
ISBN 10: 9535128590
ISBN 13: 9789535128595
Language: EN, FR, DE, ES & NL

Biological Activities and Application of Marine Polysaccharides Book Review:

Marine organisms have been under research for the last decades as a source for different active compounds with various biological activities and application in agriculture, pharmacy, medicine, environment, and industries. Marine polysaccharides from these active compounds are used as antibacterial, antiviral, antioxidant, anti-inflammation, bioremediations, etc. During the last three decades, several important factors that control the production of phytoplankton polysaccharides have been identified such as chemical concentrations, temperature, light, etc. The current book includes 14 chapters contributed by experts around the world; the chapters are categorized into three sections: Marine Polysaccharides and Agriculture, Marine Polysaccharides and Biological Activities, and Marine Polysaccharides and Industries.

Seaweed Polysaccharides

Seaweed Polysaccharides
Author: Jayachandran Venkatesan,Sukumaran Anil,Se-Kwon Kim
Publsiher: Elsevier
Total Pages: 408
Release: 2017-05-30
ISBN 10: 0128098171
ISBN 13: 9780128098172
Language: EN, FR, DE, ES & NL

Seaweed Polysaccharides Book Review:

Seaweed Polysaccharides: Isolation, Biological, and Biomedical Applications examines the isolation and characterization of algal biopolymers, including a range of new biological and biomedical applications. In recent years, significant developments have been made in algae-based polymers (commonly called polysaccharides), and in biomedical applications such as drug delivery, wound dressings, and tissue engineering. Demand for algae-based polymers is increasing and represent a potential—very inexpensive—resource for these applications. The structure and chemical modification of algal polymers are covered, as well as the biological properties of these materials – including antithrombic, anti-inflammatory, anticoagulant, and antiviral aspects. Toxicity of algal biopolymers is also covered. Finally, the book introduces and explains real world applications of algal-based biopolymers in biomedical applications, including tissue engineering, drug delivery, and biosensors. This is the first book to cover the extraction techniques, biomedical applications, and the economic perspective of seaweed polysaccharides. It is an essential text for researchers and industry professionals looking to work with this renewable resource. Provides comprehensive coverage of the research currently taking place in biomedical applications of algae biopolymers Includes practical guidance on the isolation, extraction, and characterization of polysaccharides from sustainable marine sources Covers the extraction techniques, biomedical applications, and economic outlook of seaweed polysaccharides

Industrial Applications of Marine Biopolymers

Industrial Applications of Marine Biopolymers
Author: Parappurath Narayanan Sudha
Publsiher: CRC Press
Total Pages: 608
Release: 2017-07-06
ISBN 10: 1315313510
ISBN 13: 9781315313511
Language: EN, FR, DE, ES & NL

Industrial Applications of Marine Biopolymers Book Review:

Industrial Applications of Marine Biopolymers presents different classes of marine biopolymers and their industrial applications, demonstrating the precious value of ocean resources to society. This timely volume discusses the exceedingly useful polymers derived from these materials that are biodegradable, biocompatible, and at times water soluble. Direct use or chemically modified forms of such biomaterials have many chemical sites, making them suitable for varied types of industrial applications. In addition, this book also addresses current global challenges of conservation, including extended drought conditions and the need for improved agricultural methods, together with new bio-medical developments. It is suitable for anyone who has an interest in the industrial applications of biopolymers.