Advances in Bioorganometallic Chemistry

Advances in Bioorganometallic Chemistry
Author: Toshikazu Hirao,Toshiyuki Moriuchi
Publsiher: Elsevier
Total Pages: 472
Release: 2018-11-30
ISBN 10: 0128141980
ISBN 13: 9780128141984
Language: EN, FR, DE, ES & NL

Advances in Bioorganometallic Chemistry Book Review:

Advances in Bioorganometallic Chemistry examines the synthesis, structure and reactivity of bioorganometallics, their pharmaceutical applications, hydrogenase, vitamin B12-like systems, and metalloproteins. It is written by the top researchers in the field and compiled by editors Toshikazu Hirao and Toshiyuki Moriuchi. Developments in this new field of bioorganometallic chemistry, a hybrid between biology and organometallic chemistry, happen very quickly and this comprehensive reference offers the latest research and findings in the field. The book features a discussion of the synthesis, structure, and reactivity of bioorganometallics, and an examination of hydrogenase-like systems, which were designed to demonstrate catalytic activities and functional properties. Advances in Bioorganometallic Chemistry also includes a discussion of bioorganometallics as they relate to medicinal chemistry, specifically applications of metalloproteins, metalloenzymes, and applications in bioimaging. The book concludes with coverage of vitamin B12-like systems, including the latest developments in derivatives designed to perform bio-inspired catalytic reactions. This work is a valuable resource for chemists working in organometallic chemistry and biology, including biochemists, bioorganic chemists, bioinorganic chemists, as well as pharmaceutical scientists, medicinal chemists, and students studying in these areas. Representative authors: R. H. Fish, T. Moriuchi, T. Hirao, H.-B. Kraatz, H. Takaya, T. P. Curran, G. van Koten. E. Rosenberg, J. M. Lynam, C. G. Hartinger, U. Schatzschneider, G. S. Smith, R. Alberto, S. Takenaka, T. Ihara, T. Hayashi, T. Ueno, P. Schollhammer, Y. Shomura, Y. Hisaeda, H. Shimakoshi, B. Kräutler Provides a balanced overview of the latest research in the field of bioorganometallic chemistry, drawing together the top researchers from around the world Covers topics in the areas of synthesis, reactivity, hydrogenase-like systems, medicinal chemistry, applications of metalloproteins, metalloenzymes, and applications in bioimaging

Exam Prep Flash Cards for Advances in Bioorganometallic

Exam Prep Flash Cards for Advances in Bioorganometallic
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2021
ISBN 10:
ISBN 13:
Language: EN, FR, DE, ES & NL

Exam Prep Flash Cards for Advances in Bioorganometallic Book Review:

Bioorganometallic Chemistry

Bioorganometallic Chemistry
Author: Gérard Jaouen,Michèle Salmain
Publsiher: John Wiley & Sons
Total Pages: 424
Release: 2015-04-20
ISBN 10: 3527335277
ISBN 13: 9783527335275
Language: EN, FR, DE, ES & NL

Bioorganometallic Chemistry Book Review:

An up-to-date reference reflecting the significant advances and important breakthroughs made in this emerging discipline over the last decade. As such, the book provides an overview of the latest developments and future trends in the field, focusing on such applications as the development of potentially active organometallic drugs against incurable diseases, as well as in such areas as catalysis, energy, analytical chemistry, and imaging. The renowned editor, who established the term "bioorganometallics", and his international team of experts have put together a valuable resource for researchers in organometallic, inorganic, medicinal, and biochemistry.

Advances in Organometallic Chemistry and Catalysis

Advances in Organometallic Chemistry and Catalysis
Author: Armando J. L. Pombeiro
Publsiher: John Wiley & Sons
Total Pages: 736
Release: 2013-10-11
ISBN 10: 1118742893
ISBN 13: 9781118742891
Language: EN, FR, DE, ES & NL

Advances in Organometallic Chemistry and Catalysis Book Review:

A contemporary compilation of recent achievements inorganometallic chemistry The prestigious International Conference on OrganometallicChemistry (ICOMC) was launched in 1963, providing a forum forresearchers from around the world to share their findings andexplore new paths to advance our knowledge and application oforganometallic chemistry. The 25th ICOMC, held in Lisbon in 2012,gathered more than 1,200 participants from 54 countries. Thisvolume celebrates the 25th Silver Edition and the 50th Gold Year ofthe ICOMC. Featuring contributions from invited 25th ICOMC speakers,Advances in Organometallic Chemistry and Catalysishighlights recent achievements and new and emerging areas ofresearch in the field. Its seven sections cover: Activation and Functionalization of Carbon Single Bonds andSmall Molecules Organometallic Synthesis and Catalysis Organometallic Polymerization Catalysis Organometallic Polymers and Materials Organometallic Chemistry and Sustainable Energy Bioorganometallic Chemistry Organometallic Electrochemistry Chapters discuss fundamental underlying concepts, offerillustrative examples and cases, and explore future avenues forcontinued research. Readers will discover basic principles andproperties of organometallic compounds, reaction mechanisms, anddetailed descriptions of current applications. Collectively, thesechapters underscore the versatility, richness, and potential ofmodern organometallic chemistry, including its interrelationshipswith other scientific disciplines. All the contributions are extensively referenced, providing agateway to the most important original research papers and reviewsin organometallic chemistry. Presenting a contemporaryunderstanding of organometallic chemistry and its manyapplications, Advances in Organometallic Chemistry andCatalysis is recommended for all researchers in the field, fromstudents to advanced investigators.

Bioorganometallic Chemistry

Bioorganometallic Chemistry
Author: Wolfgang Weigand,Ulf-Peter Apfel
Publsiher: Walter de Gruyter GmbH & Co KG
Total Pages: 443
Release: 2020-06-08
ISBN 10: 3110496577
ISBN 13: 9783110496574
Language: EN, FR, DE, ES & NL

Bioorganometallic Chemistry Book Review:

Bioorganometallic Chemistry is an excellent introduction to this transdisciplinary field which is straddled with biochemistry, medicine and organometallic chemistry. The book is a comprehensive review on the latest advances of this rapidly growing area, as well as historical background and future trends, revealing a tremendous potential of bioorganometallic compounds as novel drug candidates and diagnostic tools.

The Organometallic Chemistry of the Transition Metals

The Organometallic Chemistry of the Transition Metals
Author: Robert H. Crabtree
Publsiher: John Wiley & Sons
Total Pages: 520
Release: 2009-04-06
ISBN 10: 0470257628
ISBN 13: 9780470257623
Language: EN, FR, DE, ES & NL

The Organometallic Chemistry of the Transition Metals Book Review:

"One impressive and compressive book. . . . This review would have to be book size to do full justice to all the insights in this volume." —Journal of Metals Online Fully updated and expanded to reflect recent advances, this Fifth Edition of the classic text provides students and professional chemists with a comprehensive introduction to the principles and general properties of organometallic compounds, as well as including practical information on reaction mechanisms and?detailed descriptions of contemporary applications. With increased focus on organic synthesis applications, nanoparticle science, and green chemistry, the Fifth Edition brings this vital resource up to date. New to the Fifth Edition: Chapters have been updated with relevant examples in the field, modern trends, and new applications; the organic applications chapter has been completely rewritten New end-of-chapter problems, along with their solutions Coverage enhanced with developments in nanoparticle science Increased focus on green chemistry An unparalleled pedagogic resource as well as a valuable working reference for professional chemists, with comprehensive coverage and up-to-date information, students and researchers?in organic and organometallic chemistry will turn to The Organometallic Chemistry of the Transition Metals, Fifth Edition for the critical information they need on organometallic compounds, their preparation, and their use in synthesis.

Medicinal Organometallic Chemistry

Medicinal Organometallic Chemistry
Author: Gérard Jaouen,Nils Metzler-Nolte
Publsiher: Springer Science & Business Media
Total Pages: 294
Release: 2010-09-14
ISBN 10: 3642131840
ISBN 13: 9783642131844
Language: EN, FR, DE, ES & NL

Medicinal Organometallic Chemistry Book Review:

Contents: Gérard Jaouen, Nils Metzler-Nolte : Introduction ; Stéphane GIBAUD and Gérard JAOUEN: Arsenic - based drugs: from Fowler’s solution to modern anticancer chemotherapy; Ana M. Pizarro, Abraha Habtemariam and Peter J. Sadler : Activation Mechanisms for Organometallic Anticancer Complexes; Angela Casini, Christian G. Hartinger, Alexey A. Nazarov, Paul J. Dyson : Organometallic antitumour agents with alternative modes of action; Elizabeth A. Hillard, Anne Vessières, Gerard Jaouen : Ferrocene functionalized endocrine modulators for the treatment of cancer; Megan Hogan and Matthias Tacke : Titanocenes – Cytotoxic and Anti-Angiogenic Chemotherapy Against Advanced Renal-Cell Cancer; Seann P. Mulcahy and Eric Meggers : Organometallics as Structural Scaffolds for Enzyme Inhibitor Design; Christophe Biot and Daniel Dive : Bioorganometallic Chemistry and Malaria; Nils Metzler-Nolte : Biomedical applications of organometal-peptide conjugates; Roger Alberto : Organometallic Radiopharmaceuticals; Brian E. Mann : Carbon Monoxide – an essential signaling molecule.

Advances in Organometallic Chemistry

Advances in Organometallic Chemistry
Author: Pedro J. Pérez
Publsiher: Academic Press
Total Pages: 322
Release: 2014-09-25
ISBN 10: 0128010843
ISBN 13: 9780128010846
Language: EN, FR, DE, ES & NL

Advances in Organometallic Chemistry Book Review:

This book contains authoritative reviews regarding the field of Organometallic Chemistry, written by highly qualified experts within the area, and reviewed by other experts before publication. Because of this high standard, AOC is one of the most cited journals in both Organic and Inorganic Chemistry fields. High quality of the articles Expertise of authors Careful editing that provides an easy-to-read material

Advances in Anticancer Agents in Medicinal Chemistry

Advances in Anticancer Agents in Medicinal Chemistry
Author: Michelle Prudhomme
Publsiher: Bentham Science Publishers
Total Pages: 485
Release: 2013-06-14
ISBN 10: 1608054969
ISBN 13: 9781608054961
Language: EN, FR, DE, ES & NL

Advances in Anticancer Agents in Medicinal Chemistry Book Review:

Advances in Anticancer Agents in Medicinal Chemistry is an exciting eBook series comprising a selection of updated articles previously published in the peer-reviewed journal Anti-Cancer Agents in Medicinal Chemistry. The second Volume of this eBook series gathers updated reviews on several classes of molecules exhibiting anticarcinogenic potential as well as some important targets for the development of novel anticancer drugs.

Organometallic Chemistry Research Perspectives

Organometallic Chemistry Research Perspectives
Author: Richard P. Irwin
Publsiher: Nova Publishers
Total Pages: 309
Release: 2007
ISBN 10: 9781600217807
ISBN 13: 160021780X
Language: EN, FR, DE, ES & NL

Organometallic Chemistry Research Perspectives Book Review:

Organometallic chemistry is based on the reactions and use of a class of compounds (R-M) that contain a covalent bond between carbon and metal. They are prepared either by direct reaction of the metal with an organic compound or by replacement of a metal from another organometallic substance. Research in organometallic chemistry is also conducted in the areas of cluster synthesis, main-group derivatives in unusual oxidation states, organometallic polymers, unstable organometallic compounds and intermediates in matrices, structure determination of organometallic compounds in the solid state [X-ray diffraction] and gaseous states [electron diffraction], and mechanisms of reactions of transient silylenes and related species. In addition to the traditional metals and semimetals, elements such as selenium, lithium and magnesium are considered to form organometallic compounds, e.g. organomagnesium compounds MeMgI, iodo(methyl)magnesium and diethylmagnesium which are Grignard reagents an organo-lithium compound BuLi butyllithium. Organometallic compounds often find practical use as catalysts, the processing of petroleum products and the production of organic polymers. This book presents leading-edge new research in the field.

Inorganic Photochemistry

Inorganic Photochemistry
Author: Anonim
Publsiher: Academic Press
Total Pages: 464
Release: 2011-07-14
ISBN 10: 0123859050
ISBN 13: 9780123859051
Language: EN, FR, DE, ES & NL

Inorganic Photochemistry Book Review:

The Advances in Inorganic Chemistry series present timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry, ranging from bio-inorganic to solid state studies. This acclaimed serial features reviews written by experts in the field and serves as an indispensable reference to advanced researchers. Each volume contains an index, and each chapter is fully referenced. Features comprehensive reviews on the latest developments Includes contributions from leading experts in the field Serves as an indispensable reference to advanced researchers

The Organometallic Chemistry of the Transition Metals

The Organometallic Chemistry of the Transition Metals
Author: Robert H. Crabtree
Publsiher: John Wiley & Sons
Total Pages: 600
Release: 2005-06-14
ISBN 10: 0471718750
ISBN 13: 9780471718758
Language: EN, FR, DE, ES & NL

The Organometallic Chemistry of the Transition Metals Book Review:

Fully updated and expanded to reflect recent advances, this Fourth Edition of the classic text provides students and professional chemists with an excellent introduction to the principles and general properties of organometallic compounds, as well as including practical information on reaction mechanisms and detailed descriptions of contemporary applications.

Bioinorganic Chemistry Inorganic Elements in the Chemistry of Life

Bioinorganic Chemistry    Inorganic Elements in the Chemistry of Life
Author: Wolfgang Kaim,Brigitte Schwederski,Axel Klein
Publsiher: John Wiley & Sons
Total Pages: 456
Release: 2013-08-01
ISBN 10: 1118659260
ISBN 13: 9781118659267
Language: EN, FR, DE, ES & NL

Bioinorganic Chemistry Inorganic Elements in the Chemistry of Life Book Review:

The field of Bioinorganic Chemistry has grown significantly inrecent years; now one of the major sub-disciplines of InorganicChemistry, it has also pervaded other areas of the life sciencesdue to its highly interdisciplinary nature. Bioinorganic Chemistry: Inorganic Elements in the Chemistryof Life, Second Edition provides a detailed introduction to therole of inorganic elements in biology, taking a systematicelement-by-element approach to the topic. The second edition ofthis classic text has been fully revised and updated to include newstructure information, emerging developments in the field, and anincreased focus on medical applications of inorganic compounds. Newtopics have been added including materials aspects of bioinorganicchemistry, elemental cycles, bioorganometallic chemistry, medicalimaging and therapeutic advances. Topics covered include: Metals at the center of photosynthesis Uptake, transport, and storage of essential elements Catalysis through hemoproteins Biological functions of molybdenum, tungsten, vanadium andchromium Function and transport of alkaline and alkaline earth metalcations Biomineralization Biological functions of the non-metallic inorganicelements Bioinorganic chemistry of toxic metals Biochemical behavior of radionuclides and medical imaging usinginorganic compounds Chemotherapy involving non-essential elements This full color text provides a concise and comprehensive review ofbioinorganic chemistry for advanced students of chemistry,biochemistry, biology, medicine and environmental science.

Ferrocenes

Ferrocenes
Author: Petr Stepnicka
Publsiher: John Wiley & Sons
Total Pages: 670
Release: 2008-04-15
ISBN 10: 9780470985656
ISBN 13: 0470985658
Language: EN, FR, DE, ES & NL

Ferrocenes Book Review:

Ferrocene—the prototypical metallocene—is a fascinating molecule. Even though it was first discovered over fifty years ago, research into ferrocene-containing compounds continues apace, largely stimulated by their successful applications in catalysis, materials science and bioorganometallic chemistry. Ferrocene derivatives are now recognised as useful starting materials for the preparation of new organometallic complexes and functional materials, efficient catalyst components, as well as redox-active modifiers to biomolecules. Ferrocenes: Ligands, Materials and Biomolecules provides the reader with a background overview and describes recent advances in the development and application of ferrocene compounds, including: synthesis and catalytic utilisation of chiral and non-chiral ferrocene ligands ferrocene-based sensors electrooptical materials ferrocene polymers liquid-crystalline materials crystal engineering with ferrocene compounds the bioorganometallic chemistry of ferrocene Ferrocenes: Ligands, Materials and Biomolecules is an essential guide for anyone working in the fields of organometallic synthesis and catalysis, materials science and bioorganometallic chemistry.

Principles of Inorganic Chemistry

Principles of Inorganic Chemistry
Author: Brian W. Pfennig
Publsiher: John Wiley & Sons
Total Pages: 760
Release: 2015-03-30
ISBN 10: 1118859103
ISBN 13: 9781118859100
Language: EN, FR, DE, ES & NL

Principles of Inorganic Chemistry Book Review:

Aimed at senior undergraduates and first-year graduate students, this book offers a principles-based approach to inorganic chemistry that, unlike other texts, uses chemical applications of group theory and molecular orbital theory throughout as an underlying framework. This highly physical approach allows students to derive the greatest benefit of topics such as molecular orbital acid-base theory, band theory of solids, and inorganic photochemistry, to name a few. Takes a principles-based, group and molecular orbital theory approach to inorganic chemistry The first inorganic chemistry textbook to provide a thorough treatment of group theory, a topic usually relegated to only one or two chapters of texts, giving it only a cursory overview Covers atomic and molecular term symbols, symmetry coordinates in vibrational spectroscopy using the projection operator method, polyatomic MO theory, band theory, and Tanabe-Sugano diagrams Includes a heavy dose of group theory in the primary inorganic textbook, most of the pedagogical benefits of integration and reinforcement of this material in the treatment of other topics, such as frontier MO acid--base theory, band theory of solids, inorganic photochemistry, the Jahn-Teller effect, and Wade's rules are fully realized Very physical in nature compare to other textbooks in the field, taking the time to go through mathematical derivations and to compare and contrast different theories of bonding in order to allow for a more rigorous treatment of their application to molecular structure, bonding, and spectroscopy Informal and engaging writing style; worked examples throughout the text; unanswered problems in every chapter; contains a generous use of informative, colorful illustrations

Recent Progress in Organometallic Chemistry

Recent Progress in Organometallic Chemistry
Author: Mohammed Rahman,Abdullah Mohammed Asiri
Publsiher: BoD – Books on Demand
Total Pages: 148
Release: 2017-07-05
ISBN 10: 9535133179
ISBN 13: 9789535133179
Language: EN, FR, DE, ES & NL

Recent Progress in Organometallic Chemistry Book Review:

The book Recent Progress in Organometallic Chemistry mostly reviews the modem techniques and substantial organometallic and medical applications of inorganic materials. Chapters of this book are invited and contributed from the experts throughout the world from prominent researchers and scientists in the field of inorganic chemistry on organometallics and metallocenes. Each chapter provides technical and methodological details beyond the level found in typical journal articles or reviews and explores the application of organometallics, medicinal, inorganic, and catalysis to a significant problem in medical and catalysis, also providing a prospectus for the future. This book compiles with the expert knowledge of many specialists in the organic-inorganic synthesis and use of inorganic catalyst and metallocenes including chemical catalysis, biological catalysis, photo-electrocatalysis, bioassays, industrial catalysis, large-scale synthesis, micro-nanocatalyst, and so on in the field of fundamental and applied organometallic chemistry. Highlighting and importance are included on real and practical problems, ranging from industrial to medical applications and from single-multicells to animal to human objects. This offers the unique opportunity of exchanging and combining the scientist or researcher in organometallic chemistry in largely chemistry, biological, biomedical, physiological, metallocene, and inorganic chemistry fields.

Bioorganometallics

Bioorganometallics
Author: Gérard Jaouen
Publsiher: John Wiley & Sons
Total Pages: 462
Release: 2006-05-12
ISBN 10: 3527607110
ISBN 13: 9783527607112
Language: EN, FR, DE, ES & NL

Bioorganometallics Book Review:

This first comprehensive book to cover the expanding field of bioorganometallics represents the perfect starting point for beginners but also an excellent source of high quality information for experts in the field. Edited by a pioneer in the field with an excellent standing within the community, this book begins with the history of bioorganometallics, before going on to cover pharmaceuticals, bioorganometallic chemistry and radiopharmaceuticals. A must for bioinorganic chemists, the pharmaceutical industry, chemists working in organometallics and biochemists.

Bioorganometallic Chemistry

Bioorganometallic Chemistry
Author: Gerard Simonneaux
Publsiher: Springer Verlag
Total Pages: 222
Release: 2006-05-23
ISBN 10:
ISBN 13: UOM:39015064775151
Language: EN, FR, DE, ES & NL

Bioorganometallic Chemistry Book Review:

Bioorganometallic Chemistry has become a mature area of science and is comprehensively covered by leading experts in this book. Research in this rapidly developing transdisciplinary field is having profound influence on other areas of scientific investigation, ranging from catalytic organic synthesis to biology, medicine and material science. This book provides a balanced view of this rapidly developing and promising subject.

Cisplatin

Cisplatin
Author: Bernhard Lippert
Publsiher: John Wiley & Sons
Total Pages: 563
Release: 1999
ISBN 10: 9783906390208
ISBN 13: 3906390209
Language: EN, FR, DE, ES & NL

Cisplatin Book Review:

30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Divided in 6 sections and 22 chapters, the book provides an up-to-date account on topics such as - the chemistry and biochemistry of cisplatin, - the clinical status of Pt anticancer drugs, - the impact of cisplatin on inorganic and coordination chemistry, - new developments in drug design, testing and delivery. It also includes a chapter describing the historical development of the discovery of cisplatin. The ultimate question - How does cisplatin kill a cell? - is yet to be answered, but there are now new links suggesting how Pt binding to DNA may trigger a cascade of cellular reactions that eventually result in apoptosis. p53 and a series of damage recognition proteins of the HMG-domain family appear to be involved. The book addresses the problem of mutagenicity of Pt drugs and raises the question of the possible relevance of the minor DNA adducts, e.g. of interstrand cross-links, and the possible use of trans-(NH3)2Pt(II)-modified oligonucleotides in antisense and antigene strategies. Our present understanding of reactions of cisplatin with DNA is based upon numerous model studies (from isolated model nucleobases to short DNA fragments) and application of a large body of spectroscopic and other physico-chemical techniques. Thanks to these efforts there is presently no other metal ion whose reactions with nucleic acids are better understood than Pt. In a series of chapters, basic studies on the interactions of Pt electrophiles with nucleobases, oligonucleotides, DNA, amino acids, peptides and proteins are reported, which use, among others, sophisticated NMR techniques or X-ray crystallography, to get remarkable understanding of details on such reactions. Reactivity of cisplatin, once bound to DNA and formerly believed to be inert enough to stay, is an emerging phenomenon. It has (not yet) widely been studied but is potentially extremely important. Medicinal bioinorganic chemistry - the role of metal compounds in medicine - has received an enormous boost from cisplatin, and so has bioinorganic chemistry as a whole. There is hardly a better example than cisplatin to demonstrate what bioinorganic chemistry is all about: The marriage between classic inorganic (coordination) chemistry and the other life sciences - medicine, pharmacy, biology, biochemistry. Cisplatin has left its mark also on areas that are generally considered largely inorganic. The subject of mixed-valance Pt compounds is an example: From the sleeping beauty it made its way to the headlines of scientific journals, thanks to a class of novel Pt antitumor agents, the so-called "platinum pyrimidine blues". In the aftermath diplatinum (III) compounds were recognized and studies in large numbers, and now an organometalic chemistry of these diplatinum (III) species is beginning to emerge. The final section of the book is concerned with new developments such as novel di- and trinuclear Pt(II) drugs with DNA binding properties different from those of cisplatin, with orally active Pt(IV) drugs which are presently in clinical studies, and with attempts to modify combinatorial chemistry in such a way that it may become applicable to fast screening of Pt antitumor drugs. The potential of including computational methods in solving questions of Pt-DNA interactions is critically dealt with in the concluding chapter.

Organometallic Chemistry

Organometallic Chemistry
Author: Gary O. Spessard,Gary L. Miessler
Publsiher: Oxford University Press, USA
Total Pages: 671
Release: 2010
ISBN 10: 9780195330991
ISBN 13: 0195330994
Language: EN, FR, DE, ES & NL

Organometallic Chemistry Book Review:

Spessard and Miessler's Organometallic Chemistry, originally published by Prentice Hall in 1997, is widely acknowledged as the most appropriate text for undergraduates and beginning graduate students taking this course. It is a highly readable and approachable text that starts with the basic inorganic chemistry needed to understand this advanced topic. Unlike the primary competing book by Crabtree (Wiley), S/M places a strong emphasis on structure and bonding in the first several chapters, which lay the foundation for later discussion of reaction types and applications. The organization of material is much more accessible for students who have never seen organometallic chemistry before. In addition to being pitched at the right level for undergraduate students, S/M presents outstanding explanations of important core topics such as molecular orbitals and bonding and supports these discussions with detailed illustrations and praised end of chapter problems. The second edition has been significantly revised and updated to include advancements over the last ten years in NMR, IR spectroscopy, nanotechnology and physical methods. The authors have significantly updated four chapters (9, 10, 11 and 12). Chapter 9 (catalysis) has been revised to cover the advances in catalytic cycle research. Chapter 10 in the first edition, which covered carbene complexes, metathesis, and polymerization, has been divided into two chapters in view of the expanded research efforts that have occurred over the last ten years in these areas. Chapter 10 in the second edition now focuses on carbene complexes, and Chapter 11 covers aspects of metathesis and polymerization reactions including an expanded discussion of Schrock and Grubbs metal carbene catalysts. Chapter 12 (Chapter 11, first edition) is a substantially-revised treatment of the applications of organometallic chemistry to organic synthesis. This chapter offers an extensive discussion of asymmetric hydrogenationand oxidation methodology as well as a greatly revised treatment of Tsuji-Trost allylation, the Heck reaction, and palladium-catalyzed cross-coupling reactions. The latter topic includes discussion of the Stille, Suzuki, Sonogashira, and Negishi cross-couplings, reactions that have had a profound impact on the synthesis of anti-tumor compounds and other potent pharmaceuticals. In addition, the authors have included more molecular model illustrations, and introduced more modern examples and medical/medicinal applications across the text. They have included 53% more in-chapter exercises and end-of-chapter problems (23% more exercises and 81% more EOCs). The second edition has been extensively updated to include current literature (62% more references to the chemical literature).